Proanthocyanidins may protect against LDL oxidation and inhibit platelets aggregation and therefore prevent cardiovascular diseases.
(Santos-Buelga C, Scalbert A, (2000) J. of the Science of Food and Agri., 80 (7): 1094-1117 )

Oligomeric complexes may help to prevent oxidative stress and  may reduce free radicals production.
(Fujii. H. et. al. (2007) J. Agri. Food Chem., (55) 4: 1523-1531

Grape seeds proanthocyanidins extract provides excellent protection against oxidative stress.
(Bagchi, D. et. al. (2000) 148(2-3):187-197)

Proanthocyanidins may inhibit the oxidation of LDL and show anti-atherosclerotic activity.
(Yamakoshi J.. et. al. (1999) Arteriosclerosis., 142(1):139-49)

Proanthocyanidins may protect against LDL oxidation and inhibit platelets aggregation and therefore prevent cardiovascular diseases.
(Santos-Buelga C, Scalbert A, (2000) J. of the Science of Food and Agri., 80 (7): 1094-1117 )

Anti-thrombotic effect of proanthocyanidin may be due to a direct inhibitory effect on platelets.
(Sano, T. et. al. (2005) Throm. Res. 115 (1-2): 115-121)

Grape seed proanthocyanidins extract may serve as a potential therapeutic tool in promoting cardiovascular health.
(Bagchi D. et. al., (2003) Mutat. Res. 523-524:87-97.)

Grape Seed Proanthocyanidin has significant effect in the protection of heart against MI
(Karthikeyan, K., Sarala Bai, B.R., Niranjali, D.S., (2007) Int. J. Cardio. 115 (3): 326-333)

GrapeSeed Procyanidins Extract has the effect in protecting kidney of diabetic .
(Liu, Y.N., Shen, XN, Yao, GY.. (2006) WSYJ, 35(6): 703-705)

Oligomeric proanthocyanidins are shown to be beneficial to strengthening capillaries.
(Fleming T, ed. (2000) PDR for Herbal Medicines. 2nd ed. P.g. 363-364)

Proanthocyanidin: A natural crosslinking reagent for stabilizing collagen matrices
(Bo Han, Jason, J., Bao Wei, T., Marcel, E.M. (2003) J. of Biomedical Materials Res. Part A., 65 (1): 118-124)

Stabilization of collagen by procyanidolic oligomers
(Masquelier, J. Dumon, M., Dumas, J. (1981) Acta Therap., 7:101-105)